Poplar Bluff is a city in Butler County located in Southeast Missouri in the United States. It is the county seat of Butler County and is known as "The Gateway To The Ozarks" among other names. As of the 2000 U.S. Census, the city had a population of 16,651; a 2008 estimate showed the population to be 17,096, an increase of 2.67%. The Poplar Bluff Micropolitan Statistical Area consists of all of Butler County. The city is at the crossroads of U.S. Highway 60 and U.S. Highway 67.