Wellsburg is a city in Brooke County, West Virginia, ZIP code 26070. It is part of the Weirton–Steubenville, WV-OH Metropolitan Statistical Area. In 1990 it had a population of 3,385. The town was named for Alexander Wells, son-in-law of Charles Prather, builder of the first large flour warehouse in the east. The town was laid out in 1790, and its post office was opened on September 1, 1870. It is the county seat of Brooke County.