Gainesville is a city in Alachua County, Florida, United States. It is the county seat and the largest city in Alachua County. Gainesville is also home to the University of Florida, which is one of the largest universities in the United States. Santa Fe College is also located in Gainesville. The U.S. Census Bureau estimated a 2007 population of 278,375. The Gainesville, Florida Metropolitan Statistical Area (MSA), which includes Alachua and Gilchrist counties, has a population of 343,099, according to 2007 Census Bureau estimates. The Gainesville MSA was ranked as the #1 place to live in the 2007 edition of Cities Ranked and Rated. Gainesville was also ranked as one of the "best places to live and play" in 2007 by National Geographic Adventure.